Novel Platform for MRI-Guided Convection-Enhanced Delivery of Therapeutics: Preclinical Validation in Nonhuman Primate Brain

BACKGROUND/AIMS: A skull-mounted aiming device and integrated software platform has been developed for MRI-guided neurological interventions. In anticipation of upcoming gene therapy clinical trials, we adapted this device for real-time convection-enhanced delivery of therapeutics via a custom-desig...

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Bibliographische Detailangaben
Hauptverfasser: Richardson, R. Mark, Kells, Adrian P., Martin, Alastair J., Larson, Paul S., Starr, Philip A., Piferi, Peter G., Bates, Geoffrey, Tansey, Lisa, Rosenbluth, Kathryn H., Bringas, John R., Berger, Mitchel S., Bankiewicz, Krystof S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: S. Karger AG 2011
Schlagworte:
Laboratory Investigation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085040/
https://ncbi.nlm.nih.gov/pubmed/21494065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000323544
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