Novel Platform for MRI-Guided Convection-Enhanced Delivery of Therapeutics: Preclinical Validation in Nonhuman Primate Brain

BACKGROUND/AIMS: A skull-mounted aiming device and integrated software platform has been developed for MRI-guided neurological interventions. In anticipation of upcoming gene therapy clinical trials, we adapted this device for real-time convection-enhanced delivery of therapeutics via a custom-desig...

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Hlavní autoři: Richardson, R. Mark, Kells, Adrian P., Martin, Alastair J., Larson, Paul S., Starr, Philip A., Piferi, Peter G., Bates, Geoffrey, Tansey, Lisa, Rosenbluth, Kathryn H., Bringas, John R., Berger, Mitchel S., Bankiewicz, Krystof S.
Médium: Artigo
Jazyk:Inglês
Vydáno: S. Karger AG 2011
Témata:
Laboratory Investigation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085040/
https://ncbi.nlm.nih.gov/pubmed/21494065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000323544
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