Adenovirus Capsid-Based Anti-Cocaine Vaccine Prevents Cocaine from Binding to the Nonhuman Primate CNS Dopamine Transporter

Cocaine addiction is a major problem for which there is no approved pharmacotherapy. We have developed a vaccine to cocaine (dAd5GNE), based on the cocaine analog GNE linked to the capsid proteins of a serotype 5 adenovirus, designed to evoke anti-cocaine antibodies that sequester cocaine in the blo...

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Detalhes bibliográficos
Main Authors: Maoz, Anat, Hicks, Martin J, Vallabhjosula, Shankar, Synan, Michael, Kothari, Paresh J, Dyke, Jonathan P, Ballon, Douglas J, Kaminsky, Stephen M, De, Bishnu P, Rosenberg, Jonathan B, Martinez, Diana, Koob, George F, Janda, Kim D, Crystal, Ronald G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773666/
https://ncbi.nlm.nih.gov/pubmed/23660705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2013.114
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