Adenovirus Capsid-Based Anti-Cocaine Vaccine Prevents Cocaine from Binding to the Nonhuman Primate CNS Dopamine Transporter

Cocaine addiction is a major problem for which there is no approved pharmacotherapy. We have developed a vaccine to cocaine (dAd5GNE), based on the cocaine analog GNE linked to the capsid proteins of a serotype 5 adenovirus, designed to evoke anti-cocaine antibodies that sequester cocaine in the blo...

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Main Authors: Maoz, Anat, Hicks, Martin J, Vallabhjosula, Shankar, Synan, Michael, Kothari, Paresh J, Dyke, Jonathan P, Ballon, Douglas J, Kaminsky, Stephen M, De, Bishnu P, Rosenberg, Jonathan B, Martinez, Diana, Koob, George F, Janda, Kim D, Crystal, Ronald G
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2013
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Original Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773666/
https://ncbi.nlm.nih.gov/pubmed/23660705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2013.114
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