Anti-Cocaine Vaccine Based on Coupling a Cocaine Analog to a Disrupted Adenovirus

The challenge in developing an anti-cocaine vaccine is that cocaine is a small molecule, invisible to the immune system. Leveraging the knowledge that adenovirus (Ad) capsid proteins are highly immunogenic in humans, we hypothesized that linking a cocaine hapten to Ad capsid proteins would elicit hi...

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Hauptverfasser: Koob, George, Hicks, Martin J., Wee, Sunmee, Rosenberg, Jonathan B., De, Bishnu P., Kaminksy, Stephen M., Moreno, Amira, Janda, Kim D., Crystal, Ronald G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369545/
https://ncbi.nlm.nih.gov/pubmed/22229312
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