Cocaine Analog Coupled to Disrupted Adenovirus: A Vaccine Strategy to Evoke High-titer Immunity Against Addictive Drugs

Based on the concept that anticocaine antibodies could prevent inhaled cocaine from reaching its target receptors in the brain, an effective anticocaine vaccine could help reverse cocaine addiction. Leveraging the knowledge that E1(−)E3(−) adenovirus (Ad) gene transfer vectors are potent immunogens,...

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Bibliografiske detaljer
Main Authors: Hicks, Martin J, De, Bishnu P, Rosenberg, Jonathan B, Davidson, Jesse T, Moreno, Amira Y, Janda, Kim D, Wee, Sunmee, Koob, George F, Hackett, Neil R, Kaminsky, Stephen M, Worgall, Stefan, Toth, Miklos, Mezey, Jason G, Crystal, Ronald G
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048190/
https://ncbi.nlm.nih.gov/pubmed/21206484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.280
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