Cocaine Analog Coupled to Disrupted Adenovirus: A Vaccine Strategy to Evoke High-titer Immunity Against Addictive Drugs

Based on the concept that anticocaine antibodies could prevent inhaled cocaine from reaching its target receptors in the brain, an effective anticocaine vaccine could help reverse cocaine addiction. Leveraging the knowledge that E1(−)E3(−) adenovirus (Ad) gene transfer vectors are potent immunogens,...

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Detalhes bibliográficos
Main Authors: Hicks, Martin J, De, Bishnu P, Rosenberg, Jonathan B, Davidson, Jesse T, Moreno, Amira Y, Janda, Kim D, Wee, Sunmee, Koob, George F, Hackett, Neil R, Kaminsky, Stephen M, Worgall, Stefan, Toth, Miklos, Mezey, Jason G, Crystal, Ronald G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048190/
https://ncbi.nlm.nih.gov/pubmed/21206484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.280
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