Novel Cocaine Vaccine Linked to a Disrupted Adenovirus Gene Transfer Vector Blocks Cocaine Psychostimulant and Reinforcing Effects

Immunotherapy is a promising treatment for drug addiction. However, insufficient immune responses to vaccines in most subjects pose a challenge. In this study, we tested the efficacy of a new cocaine vaccine (dAd5GNE) in antagonizing cocaine addiction-related behaviors in rats. This vaccine used a d...

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Detalhes bibliográficos
Main Authors: Wee, Sunmee, Hicks, Martin J, De, Bishnu P, Rosenberg, Jonathan B, Moreno, Amira Y, Kaminsky, Stephen M, Janda, Kim D, Crystal, Ronald G, Koob, George F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306868/
https://ncbi.nlm.nih.gov/pubmed/21918504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2011.200
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