Quantitative Whole-Body Imaging of I-124-Labeled Adeno-Associated Viral Vector Biodistribution in Nonhuman Primates

A method is presented for quantitative analysis of the biodistribution of adeno-associated virus (AAV) gene transfer vectors following in vivo administration. We used iodine-124 (I-124) radiolabeling of the AAV capsid and positron emission tomography combined with compartmental modeling to quantify...

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Dades bibliogràfiques
Publicat a:Hum Gene Ther
Autors principals: Ballon, Douglas J., Rosenberg, Jonathan B., Fung, Edward K., Nikolopoulou, Anastasia, Kothari, Paresh, De, Bishnu P., He, Bin, Chen, Alvin, Heier, Linda A., Sondhi, Dolan, Kaminsky, Stephen M., Mozley, Paul David, Babich, John W., Crystal, Ronald G.
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc., publishers 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7769048/
https://ncbi.nlm.nih.gov/pubmed/33233962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2020.116
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