Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution

Archaeal DNA polymerases from the B-family (polB) have found essential applications in biotechnology. In addition, some of their variants can accept a wide range of modified nucleotides or xenobiotic nucleotides, such as 1,5-anhydrohexitol nucleic acid (HNA), which has the unique ability to selectiv...

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Publicat a:Biomolecules
Autors principals: Samson, Camille, Legrand, Pierre, Tekpinar, Mustafa, Rozenski, Jef, Abramov, Mikhail, Holliger, Philipp, Pinheiro, Vitor B., Herdewijn, Piet, Delarue, Marc
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7763228/
https://ncbi.nlm.nih.gov/pubmed/33302546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10121647
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