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A short adaptive path from DNA to RNA polymerases

DNA polymerase substrate specificity is fundamental to genome integrity and to polymerase applications in biotechnology. In the current paradigm, active site geometry is the main site of specificity control. Here, we describe the discovery of a distinct specificity checkpoint located over 25 Å from...

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Detaylı Bibliyografya
Asıl Yazarlar: Cozens, Christopher, Pinheiro, Vitor B., Vaisman, Alexandra, Woodgate, Roger, Holliger, Philipp
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361454/
https://ncbi.nlm.nih.gov/pubmed/22566643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120964109
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