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A short adaptive path from DNA to RNA polymerases
DNA polymerase substrate specificity is fundamental to genome integrity and to polymerase applications in biotechnology. In the current paradigm, active site geometry is the main site of specificity control. Here, we describe the discovery of a distinct specificity checkpoint located over 25 Å from...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3361454/ https://ncbi.nlm.nih.gov/pubmed/22566643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120964109 |
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