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A short adaptive path from DNA to RNA polymerases

DNA polymerase substrate specificity is fundamental to genome integrity and to polymerase applications in biotechnology. In the current paradigm, active site geometry is the main site of specificity control. Here, we describe the discovery of a distinct specificity checkpoint located over 25 Å from...

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書目詳細資料
Main Authors: Cozens, Christopher, Pinheiro, Vitor B., Vaisman, Alexandra, Woodgate, Roger, Holliger, Philipp
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361454/
https://ncbi.nlm.nih.gov/pubmed/22566643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120964109
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