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Biological effects of hexitol and altritol-modified siRNAs targeting B-Raf
Increasing the effectiveness of siRNAs through chemical modification is an important task. Here we describe altritol and hexitol modified oligonucleotides targeting the B-Raf oncogene that is critical for the growth and survival of melanoma cells. Using assays for apoptosis, DNA synthesis, colony fo...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2673019/ https://ncbi.nlm.nih.gov/pubmed/19374843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2009.01.030 |
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