Biological effects of hexitol and altritol-modified siRNAs targeting B-Raf

Increasing the effectiveness of siRNAs through chemical modification is an important task. Here we describe altritol and hexitol modified oligonucleotides targeting the B-Raf oncogene that is critical for the growth and survival of melanoma cells. Using assays for apoptosis, DNA synthesis, colony fo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Fisher, Michael, Abramov, Mikhail, Van Aerschot, Arthur, Rozenski, Jef, Dixit, Vidula, Juliano, Rudy L., Herdewijn, Piet
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2009
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673019/
https://ncbi.nlm.nih.gov/pubmed/19374843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2009.01.030
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