Inhibition of MDR1 expression with altritol-modified siRNAs

Altritol-modified nucleic acids (ANAs) support RNA-like A-form structures when included in oligonucleotide duplexes. Thus altritol residues seem suitable as candidates for the chemical modification of siRNAs. Here we report that ANA-modified siRNAs targeting the MDR1 gene can exhibit improved effica...

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Main Authors: Fisher, Michael, Abramov, Mikhail, Van Aerschot, Arthur, Xu, Dong, Juliano, Rudolph L., Herdewijn, Piet
格式: Artigo
語言:Inglês
出版: Oxford University Press 2007
主題:
RNA
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851637/
https://ncbi.nlm.nih.gov/pubmed/17264131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl1126
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