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Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes
The metazoan endoplasmic reticulum (ER) serves both as a hub for maturation of secreted proteins and as an intracellular calcium storage compartment, facilitating calcium-release-dependent cellular processes. ER calcium depletion robustly activates the unfolded protein response (UPR). However, it is...
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| Veröffentlicht in: | eLife |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
eLife Sciences Publications, Ltd
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7758071/ https://ncbi.nlm.nih.gov/pubmed/33295873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.62601 |
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