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MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP
Despite its known role as a secreted neuroprotectant, much of the mesencephalic astrocyte-derived neurotrophic factor (MANF) is retained in the endoplasmic reticulum (ER) of producer cells. There, by unknown mechanisms, MANF plays a role in protein folding homeostasis in complex with the ER-localize...
Uloženo v:
| Vydáno v: | Nat Commun |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group UK
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6358605/ https://ncbi.nlm.nih.gov/pubmed/30710085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08450-4 |
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