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AMPylation targets the rate-limiting step of BiP’s ATPase cycle for its functional inactivation
The endoplasmic reticulum (ER)-localized Hsp70 chaperone BiP contributes to protein folding homeostasis by engaging unfolded client proteins in a process that is tightly coupled to ATP binding and hydrolysis. The inverse correlation between BiP AMPylation and the burden of unfolded ER proteins sugge...
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| Publicat a: | eLife |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
eLife Sciences Publications, Ltd
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5667935/ https://ncbi.nlm.nih.gov/pubmed/29064368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29428 |
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