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FICD acts bi-functionally to AMPylate and de-AMPylate the endoplasmic reticulum chaperone BiP
Protein folding homeostasis in the endoplasmic reticulum (ER) is defended by an unfolded protein response (UPR) that matches ER chaperone capacity to the burden of unfolded proteins. As levels of unfolded proteins decline, a metazoan-specific FIC-domain containing ER-localized enzyme, FICD (HYPE), r...
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| Published in: | Nat Struct Mol Biol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5221731/ https://ncbi.nlm.nih.gov/pubmed/27918543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3337 |
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