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FICD acts bi-functionally to AMPylate and de-AMPylate the endoplasmic reticulum chaperone BiP
Protein folding homeostasis in the endoplasmic reticulum (ER) is defended by an unfolded protein response (UPR) that matches ER chaperone capacity to the burden of unfolded proteins. As levels of unfolded proteins decline, a metazoan-specific FIC-domain containing ER-localized enzyme, FICD (HYPE), r...
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| 出版年: | Nat Struct Mol Biol |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5221731/ https://ncbi.nlm.nih.gov/pubmed/27918543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3337 |
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