Inadequate BiP availability defines endoplasmic reticulum stress

How endoplasmic reticulum (ER) stress leads to cytotoxicity is ill-defined. Previously we showed that HeLa cells readjust homeostasis upon proteostatically driven ER stress, triggered by inducible bulk expression of secretory immunoglobulin M heavy chain (μ(s)) thanks to the unfolded protein respons...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Vitale, Milena, Bakunts, Anush, Orsi, Andrea, Lari, Federica, Tadè, Laura, Danieli, Alberto, Rato, Claudia, Valetti, Caterina, Sitia, Roberto, Raimondi, Andrea, Christianson, John C, van Anken, Eelco
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2019
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417858/
https://ncbi.nlm.nih.gov/pubmed/30869076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.41168
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