Ratiometric sensing of BiP-client versus BiP levels by the unfolded protein response determines its signaling amplitude

Insufficient folding capacity of the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to restore homeostasis. Yet, how the UPR achieves ER homeostatic readjustment is poorly investigated, as in most studies the ER stress that is elicited cannot be overcome. Here we show that...

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Udgivet i:eLife
Main Authors: Bakunts, Anush, Orsi, Andrea, Vitale, Milena, Cattaneo, Angela, Lari, Federica, Tadè, Laura, Sitia, Roberto, Raimondi, Andrea, Bachi, Angela, van Anken, Eelco
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2017
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5792092/
https://ncbi.nlm.nih.gov/pubmed/29251598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27518
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