Ratiometric sensing of BiP-client versus BiP levels by the unfolded protein response determines its signaling amplitude

Insufficient folding capacity of the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to restore homeostasis. Yet, how the UPR achieves ER homeostatic readjustment is poorly investigated, as in most studies the ER stress that is elicited cannot be overcome. Here we show that...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Bakunts, Anush, Orsi, Andrea, Vitale, Milena, Cattaneo, Angela, Lari, Federica, Tadè, Laura, Sitia, Roberto, Raimondi, Andrea, Bachi, Angela, van Anken, Eelco
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5792092/
https://ncbi.nlm.nih.gov/pubmed/29251598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27518
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