BiP Binding to the ER-Stress Sensor Ire1 Tunes the Homeostatic Behavior of the Unfolded Protein Response

The unfolded protein response (UPR) is an intracellular signaling pathway that counteracts variable stresses that impair protein folding in the endoplasmic reticulum (ER). As such, the UPR is thought to be a homeostat that finely tunes ER protein folding capacity and ER abundance according to need....

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Detalhes bibliográficos
Main Authors: Pincus, David, Chevalier, Michael W., Aragón, Tomás, van Anken, Eelco, Vidal, Simon E., El-Samad, Hana, Walter, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897766/
https://ncbi.nlm.nih.gov/pubmed/20625545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000415
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