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Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity
Accumulation of misfolded proteins in the lumen of the endoplasmic reticulum (ER) activates the unfolded protein response (UPR). Ire1, an ER-resident transmembrane kinase/RNase, senses the protein folding status inside the ER. When activated, Ire1 oligomerizes and trans-autophosphorylates, activatin...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3082176/ https://ncbi.nlm.nih.gov/pubmed/21444684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201007077 |
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