Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic

Two ER membrane-resident transmembrane kinases, IRE1 and PERK, function as stress sensors in the unfolded protein response. IRE1 also has an endoribonuclease activity, which initiates a non-conventional mRNA splicing reaction, while PERK phosphorylates eIF2α. We engineered a potent small molecule, I...

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Pubblicato in:eLife
Autori principali: Mendez, Aaron S, Alfaro, Jennifer, Morales-Soto, Marisol A, Dar, Arvin C, McCullagh, Emma, Gotthardt, Katja, Li, Han, Acosta-Alvear, Diego, Sidrauski, Carmela, Korennykh, Alexei V, Bernales, Sebastian, Shokat, Kevan M, Walter, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2015
Soggetti:
Biochemistry
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4436593/
https://ncbi.nlm.nih.gov/pubmed/25986605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05434
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