Specificity in endoplasmic reticulum-stress signaling in yeast entails a step-wise engagement of HAC1 mRNA to clusters of the stress sensor Ire1

Insufficient protein-folding capacity in the endoplasmic reticulum (ER) induces the unfolded protein response (UPR). In the ER lumen, accumulation of unfolded proteins activates the transmembrane ER-stress sensor Ire1 and drives its oligomerization. In the cytosol, Ire1 recruits HAC1 mRNA, mediating...

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Vydáno v:eLife
Hlavní autoři: van Anken, Eelco, Pincus, David, Coyle, Scott, Aragón, Tomás, Osman, Christof, Lari, Federica, Gómez Puerta, Silvia, Korennykh, Alexei V, Walter, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2014
Témata:
Biochemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279078/
https://ncbi.nlm.nih.gov/pubmed/25549299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05031
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