Hydroxamic Acids Immobilized on Resins (HAIRs): Synthesis of Dual‐Targeting HDAC Inhibitors and HDAC Degraders (PROTACs)

Inhibition of more than one cancer‐related pathway by multi‐target agents is an emerging approach in modern anticancer drug discovery. Here, based on the well‐established synergy between histone deacetylase inhibitors (HDACi) and alkylating agents, we present the discovery of a series of alkylating...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Angew Chem Int Ed Engl
Egile Nagusiak: Sinatra, Laura, Bandolik, Jan J., Roatsch, Martin, Sönnichsen, Melf, Schoeder, Clara T., Hamacher, Alexandra, Schöler, Andrea, Borkhardt, Arndt, Meiler, Jens, Bhatia, Sanil, Kassack, Matthias U., Hansen, Finn K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2020
Gaiak:
Communications
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756583/
https://ncbi.nlm.nih.gov/pubmed/32780485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202006725
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