Hydroxamic Acids Immobilized on Resins (HAIRs): Synthesis of Dual‐Targeting HDAC Inhibitors and HDAC Degraders (PROTACs)

Inhibition of more than one cancer‐related pathway by multi‐target agents is an emerging approach in modern anticancer drug discovery. Here, based on the well‐established synergy between histone deacetylase inhibitors (HDACi) and alkylating agents, we present the discovery of a series of alkylating...

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Bibliografiske detaljer
Udgivet i:Angew Chem Int Ed Engl
Main Authors: Sinatra, Laura, Bandolik, Jan J., Roatsch, Martin, Sönnichsen, Melf, Schoeder, Clara T., Hamacher, Alexandra, Schöler, Andrea, Borkhardt, Arndt, Meiler, Jens, Bhatia, Sanil, Kassack, Matthias U., Hansen, Finn K.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756583/
https://ncbi.nlm.nih.gov/pubmed/32780485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202006725
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