Oxa Analogues of Nexturastat A Demonstrate Improved HDAC6 Selectivity and Superior Antileukaemia Activity

The acetylome is important for maintaining the homeostasis of cells. Abnormal changes can result in the pathogenesis of immunological or neurological diseases, and degeneration can promote the manifestation of cancer. In particular, pharmacological intervention in the acetylome with pan‐histone deac...

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Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Pflieger, Marc, Sönnichsen, Melf, Horstick‐Muche, Nadine, Yang, Jing, Schliehe‐Diecks, Julian, Schöler, Andrea, Borkhardt, Arndt, Hamacher, Alexandra, Kassack, Matthias U., Hansen, Finn K., Bhatia, Sanil, Kurz, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8251746/
https://ncbi.nlm.nih.gov/pubmed/33629513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202001011
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