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Oxa Analogues of Nexturastat A Demonstrate Improved HDAC6 Selectivity and Superior Antileukaemia Activity

The acetylome is important for maintaining the homeostasis of cells. Abnormal changes can result in the pathogenesis of immunological or neurological diseases, and degeneration can promote the manifestation of cancer. In particular, pharmacological intervention in the acetylome with pan‐histone deac...

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Bibliografische gegevens
Gepubliceerd in:ChemMedChem
Hoofdauteurs: Pflieger, Marc, Sönnichsen, Melf, Horstick‐Muche, Nadine, Yang, Jing, Schliehe‐Diecks, Julian, Schöler, Andrea, Borkhardt, Arndt, Hamacher, Alexandra, Kassack, Matthias U., Hansen, Finn K., Bhatia, Sanil, Kurz, Thomas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8251746/
https://ncbi.nlm.nih.gov/pubmed/33629513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202001011
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