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Oxa Analogues of Nexturastat A Demonstrate Improved HDAC6 Selectivity and Superior Antileukaemia Activity

The acetylome is important for maintaining the homeostasis of cells. Abnormal changes can result in the pathogenesis of immunological or neurological diseases, and degeneration can promote the manifestation of cancer. In particular, pharmacological intervention in the acetylome with pan‐histone deac...

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Bibliografske podrobnosti
izdano v:ChemMedChem
Main Authors: Pflieger, Marc, Sönnichsen, Melf, Horstick‐Muche, Nadine, Yang, Jing, Schliehe‐Diecks, Julian, Schöler, Andrea, Borkhardt, Arndt, Hamacher, Alexandra, Kassack, Matthias U., Hansen, Finn K., Bhatia, Sanil, Kurz, Thomas
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8251746/
https://ncbi.nlm.nih.gov/pubmed/33629513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202001011
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