Hydroxamic Acids Immobilized on Resins (HAIRs): Synthesis of Dual‐Targeting HDAC Inhibitors and HDAC Degraders (PROTACs)

Inhibition of more than one cancer‐related pathway by multi‐target agents is an emerging approach in modern anticancer drug discovery. Here, based on the well‐established synergy between histone deacetylase inhibitors (HDACi) and alkylating agents, we present the discovery of a series of alkylating...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Sinatra, Laura, Bandolik, Jan J., Roatsch, Martin, Sönnichsen, Melf, Schoeder, Clara T., Hamacher, Alexandra, Schöler, Andrea, Borkhardt, Arndt, Meiler, Jens, Bhatia, Sanil, Kassack, Matthias U., Hansen, Finn K.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756583/
https://ncbi.nlm.nih.gov/pubmed/32780485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202006725
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