Multicomponent synthesis and binding mode of imidazo[1,2-a]pyridine-capped selective HDAC6 inhibitors

The multicomponent synthesis of a mini library of histone deacetylase inhibitors with imidazo[1,2-a]pyridine-based cap groups is presented. The biological evaluation led to the discovery of the hit compound MAIP-032 as a selective HDAC6 inhibitor with promising anticancer activity. The X-ray structu...

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Detalhes bibliográficos
Publicado no:Org Lett
Main Authors: Mackwitz, Marcel K. W., Hamacher, Alexandra, Osko, Jeremy D., Held, Jana, Schöler, Andrea, Christianson, David W., Kassack, Matthias U., Hansen, Finn K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5999327/
https://ncbi.nlm.nih.gov/pubmed/29790770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.8b01118
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