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Multicomponent synthesis and binding mode of imidazo[1,2-a]pyridine-capped selective HDAC6 inhibitors
The multicomponent synthesis of a mini library of histone deacetylase inhibitors with imidazo[1,2-a]pyridine-based cap groups is presented. The biological evaluation led to the discovery of the hit compound MAIP-032 as a selective HDAC6 inhibitor with promising anticancer activity. The X-ray structu...
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| Izdano u: | Org Lett |
|---|---|
| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5999327/ https://ncbi.nlm.nih.gov/pubmed/29790770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.8b01118 |
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