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Concurrent Hydrogenation of Three Functional Groups Enables Synthesis of C3´-Homologated Nucleoside Amino Acids

Internucleoside amide linkages are excellent mimics of phosphodiesters in RNA and may be used to optimize the properties of short interfering RNAs. Herein we report a remarkably straightforward, efficient and step economic synthesis of C3´-homologated uridine and adenosine amino acids starting from...

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Bibliografiske detaljer
Udgivet i:Org Lett
Main Authors: Kotikam, Venubabu, Rozners, Eriks
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7755113/
https://ncbi.nlm.nih.gov/pubmed/28731724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.7b01934
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