Autologous IgG antibodies block outgrowth of a substantial but variable fraction of viruses in the latent reservoir for HIV-1

In untreated HIV-1 infection, rapid viral evolution allows escape from immune responses. Viral replication can be blocked by antiretroviral therapy. However, HIV-1 persists in a latent reservoir in resting CD4(+) T cells, and rebound viremia occurs following treatment interruption. The reservoir, wh...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Bertagnolli, Lynn N., Varriale, Joseph, Sweet, Sarah, Brockhurst, Jacqueline, Simonetti, Francesco R., White, Jennifer, Beg, Subul, Lynn, Kenneth, Mounzer, Karam, Frank, Ian, Tebas, Pablo, Bar, Katharine J., Montaner, Luis J., Siliciano, Robert F., Siliciano, Janet D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2020
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7749285/
https://ncbi.nlm.nih.gov/pubmed/33239444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2020617117
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