Autologous IgG antibodies block outgrowth of a substantial but variable fraction of viruses in the latent reservoir for HIV-1

In untreated HIV-1 infection, rapid viral evolution allows escape from immune responses. Viral replication can be blocked by antiretroviral therapy. However, HIV-1 persists in a latent reservoir in resting CD4(+) T cells, and rebound viremia occurs following treatment interruption. The reservoir, wh...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Bertagnolli, Lynn N., Varriale, Joseph, Sweet, Sarah, Brockhurst, Jacqueline, Simonetti, Francesco R., White, Jennifer, Beg, Subul, Lynn, Kenneth, Mounzer, Karam, Frank, Ian, Tebas, Pablo, Bar, Katharine J., Montaner, Luis J., Siliciano, Robert F., Siliciano, Janet D.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7749285/
https://ncbi.nlm.nih.gov/pubmed/33239444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2020617117
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