Autologous IgG antibodies block outgrowth of a substantial but variable fraction of viruses in the latent reservoir for HIV-1

In untreated HIV-1 infection, rapid viral evolution allows escape from immune responses. Viral replication can be blocked by antiretroviral therapy. However, HIV-1 persists in a latent reservoir in resting CD4(+) T cells, and rebound viremia occurs following treatment interruption. The reservoir, wh...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Bertagnolli, Lynn N., Varriale, Joseph, Sweet, Sarah, Brockhurst, Jacqueline, Simonetti, Francesco R., White, Jennifer, Beg, Subul, Lynn, Kenneth, Mounzer, Karam, Frank, Ian, Tebas, Pablo, Bar, Katharine J., Montaner, Luis J., Siliciano, Robert F., Siliciano, Janet D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7749285/
https://ncbi.nlm.nih.gov/pubmed/33239444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2020617117
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