Autologous IgG antibodies block outgrowth of a substantial but variable fraction of viruses in the latent reservoir for HIV-1

In untreated HIV-1 infection, rapid viral evolution allows escape from immune responses. Viral replication can be blocked by antiretroviral therapy. However, HIV-1 persists in a latent reservoir in resting CD4(+) T cells, and rebound viremia occurs following treatment interruption. The reservoir, wh...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Bertagnolli, Lynn N., Varriale, Joseph, Sweet, Sarah, Brockhurst, Jacqueline, Simonetti, Francesco R., White, Jennifer, Beg, Subul, Lynn, Kenneth, Mounzer, Karam, Frank, Ian, Tebas, Pablo, Bar, Katharine J., Montaner, Luis J., Siliciano, Robert F., Siliciano, Janet D.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7749285/
https://ncbi.nlm.nih.gov/pubmed/33239444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2020617117
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