A novel quantitative approach for measuring the reservoir of latent HIV-1 proviruses

A stable latent reservoir for HIV-1 in resting CD4(+) T-cells precludes cure(1–3). Curative strategies targeting the reservoir are being tested(4,5) and require accurate, scalable reservoir assays. The reservoir was defined with quantitative viral outgrowth assays (QVOAs) for cells releasing infecti...

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Bibliografski detalji
Izdano u:Nature
Glavni autori: Bruner, Katherine M., Wang, Zheng, Simonetti, Francesco R., Bender, Alexandra M., Kwon, Kyungyoon J., Sengupta, Srona, Fray, Emily J., Beg, Subul A., Antar, Annukka A. R., Jenike, Katharine M., Bertagnolli, Lynn N., Capoferri, Adam A., Kufera, Joshua T., Timmons, Andrew, Nobles, Christopher, Gregg, John, Wada, Nikolas, Ho, Ya-Chi, Zhang, Hao, Margolick, Joseph B., Blankson, Joel N., Deeks, Steven G., Bushman, Frederic D., Siliciano, Janet D., Laird, Gregory M., Siliciano, Robert F.
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447073/
https://ncbi.nlm.nih.gov/pubmed/30700913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-0898-8
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