A novel quantitative approach for measuring the reservoir of latent HIV-1 proviruses

A stable latent reservoir for HIV-1 in resting CD4(+) T-cells precludes cure(1–3). Curative strategies targeting the reservoir are being tested(4,5) and require accurate, scalable reservoir assays. The reservoir was defined with quantitative viral outgrowth assays (QVOAs) for cells releasing infecti...

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Vydáno v:Nature
Hlavní autoři: Bruner, Katherine M., Wang, Zheng, Simonetti, Francesco R., Bender, Alexandra M., Kwon, Kyungyoon J., Sengupta, Srona, Fray, Emily J., Beg, Subul A., Antar, Annukka A. R., Jenike, Katharine M., Bertagnolli, Lynn N., Capoferri, Adam A., Kufera, Joshua T., Timmons, Andrew, Nobles, Christopher, Gregg, John, Wada, Nikolas, Ho, Ya-Chi, Zhang, Hao, Margolick, Joseph B., Blankson, Joel N., Deeks, Steven G., Bushman, Frederic D., Siliciano, Janet D., Laird, Gregory M., Siliciano, Robert F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447073/
https://ncbi.nlm.nih.gov/pubmed/30700913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-0898-8
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