Pilot Study Assessing Tolerability and Metabolic Effects of Metformin in Patients With Li-Fraumeni Syndrome

BACKGROUND: Li-Fraumeni syndrome (LFS) is a highly penetrant autosomal dominant cancer predisposition disorder caused by germline TP53 pathogenic variants. Patients with LFS have increased oxidative phosphorylation capacity in skeletal muscle and oxidative stress in blood. Metformin inhibits oxidati...

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Detalhes bibliográficos
Publicado no:JNCI Cancer Spectr
Main Authors: Walcott, Farzana L, Wang, Ping-Yuan, Bryla, Christine M, Huffstutler, Rebecca D, Singh, Neha, Pollak, Michael N, Khincha, Payal P, Savage, Sharon A, Mai, Phuong L, Dodd, Kevin W, Hwang, Paul M, Fojo, Antonio T, Annunziata, Christina M
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7746650/
https://ncbi.nlm.nih.gov/pubmed/33490865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jncics/pkaa063
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