Inhibiting mitochondrial respiration prevents cancer in a mouse model of Li-Fraumeni syndrome

Li-Fraumeni syndrome (LFS) is a cancer predisposition disorder caused by germline mutations in TP53 that can lead to increased mitochondrial metabolism in patients. However, the implications of altered mitochondrial function for tumorigenesis in LFS are unclear. Here, we have reported that genetic o...

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Vydáno v:J Clin Invest
Hlavní autoři: Wang, Ping-yuan, Li, Jie, Walcott, Farzana L., Kang, Ju-Gyeong, Starost, Matthew F., Talagala, S. Lalith, Zhuang, Jie, Park, Ji-Hoon, Huffstutler, Rebecca D., Bryla, Christina M., Mai, Phuong L., Pollak, Michael, Annunziata, Christina M., Savage, Sharon A., Fojo, Antonio Tito, Hwang, Paul M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2016
Témata:
Brief Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199691/
https://ncbi.nlm.nih.gov/pubmed/27869650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88668
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