Pilot Study Assessing Tolerability and Metabolic Effects of Metformin in Patients With Li-Fraumeni Syndrome

BACKGROUND: Li-Fraumeni syndrome (LFS) is a highly penetrant autosomal dominant cancer predisposition disorder caused by germline TP53 pathogenic variants. Patients with LFS have increased oxidative phosphorylation capacity in skeletal muscle and oxidative stress in blood. Metformin inhibits oxidati...

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Detaylı Bibliyografya
Yayımlandı:JNCI Cancer Spectr
Asıl Yazarlar: Walcott, Farzana L, Wang, Ping-Yuan, Bryla, Christine M, Huffstutler, Rebecca D, Singh, Neha, Pollak, Michael N, Khincha, Payal P, Savage, Sharon A, Mai, Phuong L, Dodd, Kevin W, Hwang, Paul M, Fojo, Antonio T, Annunziata, Christina M
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7746650/
https://ncbi.nlm.nih.gov/pubmed/33490865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jncics/pkaa063
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