Pilot Study Assessing Tolerability and Metabolic Effects of Metformin in Patients With Li-Fraumeni Syndrome

BACKGROUND: Li-Fraumeni syndrome (LFS) is a highly penetrant autosomal dominant cancer predisposition disorder caused by germline TP53 pathogenic variants. Patients with LFS have increased oxidative phosphorylation capacity in skeletal muscle and oxidative stress in blood. Metformin inhibits oxidati...

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Publicat a:JNCI Cancer Spectr
Autors principals: Walcott, Farzana L, Wang, Ping-Yuan, Bryla, Christine M, Huffstutler, Rebecca D, Singh, Neha, Pollak, Michael N, Khincha, Payal P, Savage, Sharon A, Mai, Phuong L, Dodd, Kevin W, Hwang, Paul M, Fojo, Antonio T, Annunziata, Christina M
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7746650/
https://ncbi.nlm.nih.gov/pubmed/33490865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jncics/pkaa063
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