Penetrance of different cancer types in families with Li-Fraumeni syndrome: a validation study using multi-center cohorts

Li-Fraumeni syndrome (LFS) is a rare hereditary cancer syndrome associated with an autosomal dominant mutation inheritance in the TP53 tumor suppressor gene and a wide spectrum of cancer diagnoses. The previously developed R package, LFSPRO, is capable of estimating the risk of an individual being a...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Shin, Seung Jun, Dodd-Eaton, Elissa B., Peng, Gang, Bojadzieva, Jasmina, Chen, Jingxiao, Amos, Christopher I., Frone, Megan N., Khincha, Payal, Mai, Phuong L., Savage, Sharon A., Ballinger, Mandy L., Thomas, David M., Yuan, Ying, Strong, Louise C., Wang, Wenyi
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980689/
https://ncbi.nlm.nih.gov/pubmed/31719101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-0728
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