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Penetrance of different cancer types in families with Li-Fraumeni syndrome: a validation study using multi-center cohorts

Li-Fraumeni syndrome (LFS) is a rare hereditary cancer syndrome associated with an autosomal dominant mutation inheritance in the TP53 tumor suppressor gene and a wide spectrum of cancer diagnoses. The previously developed R package, LFSPRO, is capable of estimating the risk of an individual being a...

詳細記述

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書誌詳細
出版年:Cancer Res
主要な著者: Shin, Seung Jun, Dodd-Eaton, Elissa B., Peng, Gang, Bojadzieva, Jasmina, Chen, Jingxiao, Amos, Christopher I., Frone, Megan N., Khincha, Payal, Mai, Phuong L., Savage, Sharon A., Ballinger, Mandy L., Thomas, David M., Yuan, Ying, Strong, Louise C., Wang, Wenyi
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980689/
https://ncbi.nlm.nih.gov/pubmed/31719101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-0728
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