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Penetrance of different cancer types in families with Li-Fraumeni syndrome: a validation study using multi-center cohorts

Li-Fraumeni syndrome (LFS) is a rare hereditary cancer syndrome associated with an autosomal dominant mutation inheritance in the TP53 tumor suppressor gene and a wide spectrum of cancer diagnoses. The previously developed R package, LFSPRO, is capable of estimating the risk of an individual being a...

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Detaylı Bibliyografya
Yayımlandı:Cancer Res
Asıl Yazarlar: Shin, Seung Jun, Dodd-Eaton, Elissa B., Peng, Gang, Bojadzieva, Jasmina, Chen, Jingxiao, Amos, Christopher I., Frone, Megan N., Khincha, Payal, Mai, Phuong L., Savage, Sharon A., Ballinger, Mandy L., Thomas, David M., Yuan, Ying, Strong, Louise C., Wang, Wenyi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980689/
https://ncbi.nlm.nih.gov/pubmed/31719101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-0728
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