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Penetrance estimates over time to first and second primary cancer diagnosis in families with Li-Fraumeni syndrome: a single institution perspective

Li-Fraumeni syndrome (LFS) is a rare autosomal dominant disorder associated with TP53 germline mutations and an increased lifetime risk of multiple primary cancers (MPC). Penetrance estimation of time to first and second primary cancer within LFS remains challenging due to limited data and the diffi...

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Dades bibliogràfiques
Publicat a:Cancer Res
Autors principals: Shin, Seung Jun, Dodd-Eaton, Elissa B., Gao, Fan, Bojadzieva, Jasmina, Chen, Jingxiao, Kong, Xianhua, Amos, Christopher I., Ning, Jing, Strong, Louise C., Wang, Wenyi
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980737/
https://ncbi.nlm.nih.gov/pubmed/31719099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-0725
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