Penetrance estimates over time to first and second primary cancer diagnosis in families with Li-Fraumeni syndrome: a single institution perspective

Li-Fraumeni syndrome (LFS) is a rare autosomal dominant disorder associated with TP53 germline mutations and an increased lifetime risk of multiple primary cancers (MPC). Penetrance estimation of time to first and second primary cancer within LFS remains challenging due to limited data and the diffi...

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Bibliographic Details
Published in:Cancer Res
Main Authors: Shin, Seung Jun, Dodd-Eaton, Elissa B., Gao, Fan, Bojadzieva, Jasmina, Chen, Jingxiao, Kong, Xianhua, Amos, Christopher I., Ning, Jing, Strong, Louise C., Wang, Wenyi
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980737/
https://ncbi.nlm.nih.gov/pubmed/31719099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-0725
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