Penetrance estimates over time to first and second primary cancer diagnosis in families with Li-Fraumeni syndrome: a single institution perspective

Li-Fraumeni syndrome (LFS) is a rare autosomal dominant disorder associated with TP53 germline mutations and an increased lifetime risk of multiple primary cancers (MPC). Penetrance estimation of time to first and second primary cancer within LFS remains challenging due to limited data and the diffi...

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Vydáno v:Cancer Res
Hlavní autoři: Shin, Seung Jun, Dodd-Eaton, Elissa B., Gao, Fan, Bojadzieva, Jasmina, Chen, Jingxiao, Kong, Xianhua, Amos, Christopher I., Ning, Jing, Strong, Louise C., Wang, Wenyi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980737/
https://ncbi.nlm.nih.gov/pubmed/31719099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-0725
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