Inhibiting mitochondrial respiration prevents cancer in a mouse model of Li-Fraumeni syndrome

Li-Fraumeni syndrome (LFS) is a cancer predisposition disorder caused by germline mutations in TP53 that can lead to increased mitochondrial metabolism in patients. However, the implications of altered mitochondrial function for tumorigenesis in LFS are unclear. Here, we have reported that genetic o...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Wang, Ping-yuan, Li, Jie, Walcott, Farzana L., Kang, Ju-Gyeong, Starost, Matthew F., Talagala, S. Lalith, Zhuang, Jie, Park, Ji-Hoon, Huffstutler, Rebecca D., Bryla, Christina M., Mai, Phuong L., Pollak, Michael, Annunziata, Christina M., Savage, Sharon A., Fojo, Antonio Tito, Hwang, Paul M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199691/
https://ncbi.nlm.nih.gov/pubmed/27869650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88668
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