Increased Oxidative Metabolism in the Li–Fraumeni Syndrome

There is growing evidence that alterations in metabolism may contribute to tumorigenesis. Here, we report on members of families with the Li–Fraumeni syndrome who carry germline mutations in TP53, the gene encoding the tumor-suppressor protein p53. As compared with family members who are not carrier...

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Main Authors: Wang, Ping-yuan, Ma, Wenzhe, Park, Joon-Young, Celi, Francesco S., Arena, Ross, Choi, Jeong W., Ali, Qais A., Tripodi, Dotti J., Zhuang, Jie, Lago, Cory U., Strong, Louise C., Talagala, S. Lalith, Balaban, Robert S., Kang, Ju-Gyeong, Hwang, Paul M.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123210/
https://ncbi.nlm.nih.gov/pubmed/23484829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1214091
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