Cohesin mutations are synthetic lethal with stimulation of WNT signaling

Mutations in genes encoding subunits of the cohesin complex are common in several cancers, but may also expose druggable vulnerabilities. We generated isogenic MCF10A cell lines with deletion mutations of genes encoding cohesin subunits SMC3, RAD21, and STAG2 and screened for synthetic lethality wit...

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Publicado en:eLife
Autores principales: Chin, Chue Vin, Antony, Jisha, Ketharnathan, Sarada, Labudina, Anastasia, Gimenez, Gregory, Parsons, Kate M, He, Jinshu, George, Amee J, Pallotta, Maria Michela, Musio, Antonio, Braithwaite, Antony, Guilford, Parry, Hannan, Ross D, Horsfield, Julia A
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cancer Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7746233/
https://ncbi.nlm.nih.gov/pubmed/33284104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61405
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