Cohesin mutations are synthetic lethal with stimulation of WNT signaling

Mutations in genes encoding subunits of the cohesin complex are common in several cancers, but may also expose druggable vulnerabilities. We generated isogenic MCF10A cell lines with deletion mutations of genes encoding cohesin subunits SMC3, RAD21, and STAG2 and screened for synthetic lethality wit...

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Vydáno v:eLife
Hlavní autoři: Chin, Chue Vin, Antony, Jisha, Ketharnathan, Sarada, Labudina, Anastasia, Gimenez, Gregory, Parsons, Kate M, He, Jinshu, George, Amee J, Pallotta, Maria Michela, Musio, Antonio, Braithwaite, Antony, Guilford, Parry, Hannan, Ross D, Horsfield, Julia A
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2020
Témata:
Cancer Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7746233/
https://ncbi.nlm.nih.gov/pubmed/33284104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61405
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