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Synthetic Lethality and Cancer: Cohesin and PARP at the Replication Fork

Cohesins are mutated in a significant number of tumors of various types making them an attractive target for chemotherapeutic intervention. However, cohesins have a spectrum of cellular roles including sister chromatid cohesion, transcription, replication, and repair. Which of these roles are centra...

詳細記述

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書誌詳細
主要な著者: O’Neil, Nigel J., van Pel, Derek M., Hieter, Philip
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868440/
https://ncbi.nlm.nih.gov/pubmed/23333522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tig.2012.12.004
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